Sent to Destroy
نویسندگان
چکیده
منابع مشابه
Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.
The ubiquitin proteasome system (UPS) plays a crucial role in biological processes integral to the development of the cardiovascular system and cardiovascular diseases. The UPS prototypically recognizes specific protein substrates and places polyubiquitin chains on them for subsequent destruction by the proteasome. This system is in place to degrade not only misfolded and damaged proteins, but ...
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itotic spindle positioning involves a con-formational switch in LGN, the mammalian version of the invertebrate Pins protein, duces a spindle rocking that represents the first genetically manipulable model for studying spindle positioning in vertebrates. The switch operates via the opening of LGN, which can normally fold back onto itself. The unfolding is triggered by binding to either membrane-...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2010
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.109.208801